Afshan Bhurgri, a cancer survivor, advises women to listen to their bodies and be aware of the symptoms of cervical cancer. Credit: Zofeen Ebrahim/IPS

By Zofeen Ebrahim
KARACHI, Jul 26 2023 (IPS)

“Listen to your body, and if there is anything strange happening, do not ignore it,” is the advice of 57-year-old Afshan Bhurgri, a cancer survivor.

Eight years ago, she was diagnosed with cervical cancer at a time when she was “in a good place” in life. Her kids were grown up, and she had more time to herself. A fitness freak, the schoolteacher’s daily routine included going to the gym daily. “I joined a creative writing class as I loved penning my thoughts!” she reminisced. 

But then everything changed when she found out she had cancer.

Cancer of the cervix uteri is the fourth most common cancer among women worldwide, with an estimated 604,127 new cases and causing the death of 341,831 in 2020.

In Pakistan, an estimated 73.8 million women over the age of 15 are at risk of developing cervical cancer caused by the human papillomavirus (HPV).

Cervical cancer in Pakistan, according to the WHO. Credit: Shahzeb Ahmed

In the absence of complete data, it is estimated that of the 5,000 women diagnosed with this cancer in Pakistan, some 3,000 lose their lives every year due to lack of access to prevention, screening and treatment, thus making it the third leading cause of cancer-related deaths in women of the reproductive age group in the country, after breast and ovarian cancers. Up to 88 percent of cervical cancer cases are due to human papillomavirus (HPV) serotypes 16 and 18, as reported by the International Agency for Research on Cancer.

“We are short on authentic data on the prevalence of the disease burden,” said Dr Arshad Chandio, who works at Jhpiego Pakistan as an immunisation lead. His organisation, which has supported HPV vaccine introduction in seven countries with Gavi support, is partnering with the federal and provincial governments, along with WHO, UNICEF, and USAID, to implement a roadmap for cervical cancer prevention and introduction of HPV vaccine in Pakistan. Cervical cancer is the only cancer that is preventable by a vaccine.

Cervical cancer worldwide, according to the WHO. Credit: Shahzeb Ahmed

“Without authentic data, our plan to eradicate this disease will not be watertight,” admitted Dr Irshad Memon, the director general of the Expanded Programme on Immunisation in Sindh.

Dr Shahid Pervez, senior consultant histopathologist at the Aga Khan University Hospital (AKUH), co-chair of the country’s newly established National Cancer Registry, recommends legislation to make reporting of cancer mandatory. “This will be one way of collecting basic data, at one place, which is expected by international agencies to roll out an effective cancer control programme in Pakistan,” he added.

Cervical cancer warning signs. Credit: Shahzeb Ahmed

Although Bhurgri had knowledge about cancer of the cervix and went for regular health checkups and screenings, her doctors did not carry out full examinations, which led to the infection turning cancerous. It all started in 2009, five years prior to being diagnosed with cancer when she started noticing a “foul smell emanating from my vagina” after her period became “heavier” than usual.

“Let alone screening and testing for the cancer, many healthcare professionals do not even know of the disease, or how women get infected,” pointed out Chandio.

“I am an educated person, I could afford to get the best medical help, and I went to three of the city’s top gynaecologists, got pap smears done on their requests over the years, and I was only sent for HPV test when it was too late,” rued Bhurgri. In 2014, a doctor suggested an ultrasound which gave a true picture. A biopsy confirmed she had cervical cancer.

After her biopsy, Bhurgri started reading up on cervical cancer, and one of the indications was the foul vaginal smell.

“It could have been nipped in the bud if only the doctors had carried out a thorough examination,” said gynaecologist and obstetrician Dr Azra Ahsan, president of the Association for Mothers and Newborns, blaming “sheer negligence” on the part of her fraternity.

“A gynaecological consultation must not only be limited to a conversation across the table,” said Ahsan, but should include an “examination on the couch including a proper internal examination, ideally a pap smear and visual inspection,” especially if, like Bhurgri, a patient was complaining of heavy bleeding and a foul smell.

Bhurgri’s journey towards wellness was tough. A radical hysterectomy was recommended, and her cervix, her uterus and her ovaries were removed. Twenty-eight radiations and five chemos later, over a five-month period, she was given a clean chit by her oncologist.

Screening Can Save Lives

Although Bhurgri’s cancer may have remained under the radar despite regular screening via pap smears, doctors say HPV and pap smear tests are the best way to screen a woman for cervical cancer. They can identify patients who are at high risk of developing pre-cancerous changes on the cervix as well as pick up those who have already developed these changes.

These precancerous lesions can be treated before they turn into cancer. Sadly, in Pakistan, the uptake of pap smears is negligible and estimated to be as low as 2 percent.

According to Dr Uzma Chishti, assistant professor and consultant gynecologic oncologist, Department of Obstetrics and Gynecology, AKUH, Pakistan’s health system is so financially stretched that it cannot afford to provide screening of women by these expensive tests. Instead, she recommends WHO’s recommendations of performing a visual inspection of the cervix by acetic acid (VIA) to screen women to help reduce the incidence of cervical cancer. “VIA is an alternative screening test for low-and-middle-income countries like ours,” she said.

Vaccinations the Best Option

The WHO triple intervention recommendation to eliminate cervical cancer in countries like Pakistan includes scaling up HPV vaccination to 90 percent for girls aged between 9 to 14, twice-lifetime cervical screening to 70 percent and treatment of pre-invasive lesions and invasive cancer to 90 percent by 2030. “All three are essential if we want to eliminate cervical cancer completely,” emphasised said Ahsan.

HPV vaccinations to prevent cervical cancer are the way forward as it provides primary prevention, said Chishti, in the absence of VIA, screenings and pap smear tests. Almost 60 per cent of cervical cancer cases occur in countries that have not yet introduced HPV vaccination. Pakistan is one of them.

Once up and about, the first thing Bhurgri did was get her 14-year-old daughter vaccinated for human papillomavirus (HPV) vaccine. “My older daughter remains unvaccinated as she was 21 then and studying abroad. She needed three shots and could not make it to that timeline,” she said.

In Pakistan, two globally licensed HPV vaccines – Cervarix (protective against HPV serotypes 16 and 18) and Gardasil (against 6, 11, 16, and 18) were available till a few years ago, but very few doctors, even in the private sector, were prescribing them.

“We made it available in our clinic and counselled any and everyone, but it mostly fell on deaf ears, and very few people actually got vaccinated. As a result, huge amounts of vaccines expired in the warehouses, and the pharmaceutical firms decided to not make it available in Pakistan,” explained Ahsan.

In 2021, medical students at the AKUH interviewed 384 women attending outpatient clinics between the ages of 15 to 50 to find out their knowledge about cervical cancer. They found that of the 61.2 percent of women who had heard about cervical cancer, 47.0 percent knew about pap smear tests, and among them, 73 percent had gotten a pap test. A total of 25.5 percent of women, out of the 61.2 percent, knew that a vaccine existed for prevention, but only 9.8 percent had been vaccinated against human papillomavirus. The study concluded that a majority of the women interviewed for the study belonged to a higher socioeconomic class and were mostly educated, yet their knowledge regarding the prevention and screening of cervical cancer was poor. “This reflects that the knowledge levels as a whole would be considerably lower in the city’s general population,” the study concluded.

But this may change if Pakistan introduces the HPV vaccine at a national level, utilising routine effective and established immunisation delivery strategies. According to Dr Uzma Shamsi, a cancer epidemiologist at the AKUH, implementing the HPV vaccine at a national level in Pakistan could save hundreds of thousands of lives annually.

Shamsi highlighted the challenges of discussing HPV in a conservative society where sexual health topics are hardly discussed due to the embarrassment and taboo associated with sexually transmitted infections (STIs). This communication conundrum has resulted in a general lack of information about the disease. “There is a total lack of information about HPV, cervical cancer, and its prevention among the masses,” she said.

But the benefits are enormous, and hundreds of thousands of lives could be saved each year, she emphasised.

Pakistan is in talks with Gavi the vaccine alliance, to support the country in including the single-dose HPV (two covers four strains) vaccine in its routine immunisation programme. “It will probably take another two years and USD 16 million before we can roll out the vaccine, but when it happens, it will be a country-wide campaign,” confirmed Memon.

Shamsi predicted some tribulation because the primary target group for vaccination is pre-adolescent girls. “A new vaccine for a new target age group comes with its own set of challenges in a society where conspiracy theories about vaccination programmes, stigma and misinformation about cancer and sexual health persist,” she said. And so before the actual rollout,  Shamsi emphasised, it was important to increase awareness about the HPV virus, cervical cancer causes, and vaccine’s safety and usage among the general public, patients, and healthcare professionals while actively dispelling misinformation.

Memon agreed that “conversation around the vaccine must begin”. For its part, the Sindh government set aside Rs 100 million ($365,884) for advocacy of HPV vaccine uptake in its current budget. “We will initiate a dissemination campaign once we know when the HPV vaccination programme is to begin,” he said. The Sindh province was also the first to initiate the typhoid conjugate virus vaccine after an extensively drug-resistant virus was found in the province. He was hopeful there would be less resistance to the HPV vaccine after the successful administration of measles and rubella and the pediatric Covid-19 vaccines earlier.

However, said Memon, “We will need more women vaccinators this time as young girls are shy of rolling their shirt sleeves up for male vaccinators.” With up to 125,000 female health workers across Pakistan, who were earlier trained by Gavi for MR immunisation, which is a much more difficult vaccine to administer (being subcutaneous) as opposed to the HPV one (which is muscular), he said, this workforce can be engaged to get trained for this vaccination campaign too.

In the end, however, according to Chandio, “without a strong political will and leadership, a national HPV vaccination programme cannot become a reality in Pakistan to eliminate this largely preventable cancer among women”.

Fighting her cancer has changed Bhurgri in more ways than one. Her message to women is to “not put yourself aside; make yourself a priority.” While she continues to lead a healthy life – going to the gym, eating healthy, resting, she said, “You cannot go on and pick up where you left off”.

Note: This feature was supported by the Sabin Vaccine Institute.

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A young boy in Pakistan receives an oral polio vaccine (OPV). Over the last 30 years huge progress has been made against polio and it is now only endemic in 2 countries, Afghanistan and Pakistan, with only 33 cases confirmed cases last year. Credit: Ashfaq Yusufzai/IPS

By Tharanga Yakupitiyage
UNITED NATIONS, May 1 2019 (IPS)

Since the introduction of vaccines, diseases such as measles and polio were quickly becoming a thing of the past. However, the world’s progress on immunisation is now being threatened.

According to the World Health Organisation (WHO), 85 percent of the world’s children received basic vaccines, including the measles and diptheria-tetanus-pertussis (DTP) vaccines, which can protect them from infectious diseases that cause serious illness and even death.

In fact, measles immunisation resulted in an 80 percent drop in measles-related deaths between 2000 and 2017 worldwide.

Still, access to vaccines remain elusive for many out-of-reach communities.

In 2017, an estimated 20 million infants did not receive the DTP vaccine, 60 percent of whom live in just 10 countries, including Afghanistan, the Democratic Republic of the Congo, Iraq, and Nigeria.

A rising anti-vaccination movement is also threatening to dismantle progress.

In the United States, there are now more than 700 cases of measles across 22 states making it the highest figures the country has seen since 2000.

The phenomenon has prompted some states to not only make immunisation mandatory, but also to ban unvaccinated children from public spaces.

To mark World Immunisation Week, held during the last week of April, IPS spoke to WHO’s Coordinator of the Expanded Programme on Immunisation Dr. Ann Lindstrand on the challenges of immunisation and the way forward. Excerpts of the interview follow:

World Health Organisation’s Coordinator of the Expanded Programme on Immunisation Dr. Ann Lindstrand.

Inter Press Service (IPS): How is the overall global picture regarding immunisation, and why does immunisation matter? 

AL: Immunisation matters because it is one of the most effective health interventions that we have, and it has saved millions of lives. I don’t think there is any other health intervention that works that well, with such high coverage, worldwide.

Just looking back at what we have gained from immunisation—back in 1963 when we didn’t have any vaccine for measles, there were about 2.6 million deaths every year due to measles. Now, that figure has reduced by 95 percent. The last figures we have are from 2017 with an estimated 110,000 deaths—so there has been a tremendous health gain.

Same with polio—30 years ago, we had widespread polio crippling people but now its only endemic in two countries Afghanistan and Pakistan with only 33 cases confirmed cases last year.

Now the newer vaccines like HPV [human papillomavirus] will help us reduce numbers of cervical cancers and new vaccines on the horizon like the Ebola vaccine which is used in outbreaks in Africa right now has really played a critical role in stopping the spread of the current outbreak in the DRC.

Just this month, the first ever malaria vaccine is being piloted in routine immunisation programs in three countries.

We still need to reach more. We still need to reach the last 15 percent and we need to close equity gaps to reach those furthest away.

IPS: WHO and others have pointed to the anti-vaccination movement as one of the biggest health threats in the world. How concerning is the move away from vaccinations, and what does this mean for people around the world? Is this a new challenge for WHO? 

AL: It is an area of concern, yes.

But it is not the global picture. We do not have the data to say that hesitancy has increased but we have seen that with social media and the internet, misinformation is spread more widely and easily.

That’s something we are really worried about. In some areas, there is a resurgence of disease because of unacceptably low coverage rates or that people are refusing vaccines.

We need to see this in a historic perspective. Anti-vaccine messages have been around for just as long as vaccines have been around—these things come and they go.

But it worries us and we need to be right there to tackle to spread of vaccine misinformation. It is really important to put out the right messages.

I work as a paediatrician and I have talked to a lot of parents who have had these concerns and it takes a lot of effort.

At the heart of it, it is really the health worker who is sitting there with the [parent] who have concerns or have heard something on the internet or media, and they need to be able to respond to their questions and to listen and respect the concerns of parents.

And that those health workers actually have the capacity and time to respond, both with the social ability to listen to the parents’ real concerns and also provide the scientific evidence.

There is a lot of work in training healthcare workers which is ongoing and we need to keep doing that. We need to equip healthcare workers with the right methods, words, scientific evidence to reassure parents.

The bigger picture for us to improve health is for children everywhere to get vaccinated on time and every time. We need to increase access so that vaccine services are made convenient and welcoming so people want to go there, that we are good at putting out credible information from the beginning including what are the facts, what is the evidence.

IPS: Some U.S. states are enacting mandatory immunisation laws or even barring those who have not received vaccines from certain public spaces. Do you agree with these steps, or does more need to be done? 

AL: The only disease where WHO actually recommends mandatory proof of vaccination applies to yellow fever and for international travellers in certain countries.

Beyond that, it is up to every country to make decisions based on existing disease epidemiology, their laws and regulations, and if it is the best way to go.

Many countries have achieved high immunisation coverage without mandatory immunisation.

It is a complex area—how do you sanction parents? How far do you go to enforce laws when they are in place?

That is a conversation that every country needs to have before even considering any of the mandatory vaccinations.

I think it is important to encourage countries to invest in and protect their individuals and communities from vaccine-preventable diseases and then remove barriers—have few access barriers when it comes to cost and convenience.

Make it simple and easy. Make the choice of vaccines the social norm.

IPS: In light of World Immunisation Week, what is your message for people around the world regarding the importance of immunisation?  

AL: Immunisation is a fantastic health intervention. It is a right for all children, and it is also a shared responsibility.

As we have seen with the recent outbreaks, no country and no individual can afford to be complacent about vaccines. It is important that we look at not just putting out fires or responding to outbreaks after they have happened—that’s expensive, ineffective and it costs lives.

What is more important is to have sustainable prevention, thinking and ensuring that everyone everywhere is vaccinated at the right time with the right vaccines and throughout their life course.

It also important to see that vaccines is not just for saving lives, it helps children to learn, grow, keep them in school instead of sick, avert disabilities and long-term consequences. It reduces the health care costs for a country, and protects families and communities from sliding into poverty.

There is no debate to have on the benefit or the risk between vaccines and the vaccine-preventable diseases.

We need to continue to protect people also in the future, and we really need to invest in trust in vaccines and in our healthcare system.

Excerpt: